Biomarkers

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ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
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18F-AV-1451 (F 18 T807)

Method of Measurement (Pre-analytical Tools)
Imaging
Biomarker Measured
Tau
Use
Prognostic
Susceptibility/risk
Stage of Development
Clinical trials
Active vs Completed Trials
Active
Aim/Results

The purpose of this research study is to evaluate a new radioactive compound used in positron emission tomography (PET) scans in identifying tau tangles (a certain protein that might be associated with Dominantly Inherited Alzheimer's Disease) in the brain, and if the amount of tau tangles in the brain has a relationship to cognitive status.

Target Population/ Population Being Studied

Patients with Dominantly Inherited Alzheimer's Disease

Length of Current Trial
5 years
Number of Trial Participants

130 (Protocol D)

Estimated Trial Completion
February 2020 (Protocol D)
What is Required from Patients

injection of radioactive tracers, mild discomfort, in clinic visit

What is Required from the Health System

PET technician, PET scanner, dyes

Sponsor

Washington University School of Medicine

  1. “Evaluating the Relationship Between Tau PET Imaging and CSF Biomarkers of AD (Alzheimer Disease) in Humans (ADRC proj 1).” ClinicalTrials.gov. Accessed October 9, 2020. https://clinicaltrials.gov/ct2/show/NCT03287765?term=biomarker&recrs=abdf&cond=Alzheimer+Disease&rank=9

  2. “F 18 T807 Tau PET Imaging in Dominantly Inherited Alzheimer's Network (DIAN Project) (AV ADAD).” ClinicalTrials.gov. Accessed October 9, 2019. https://clinicaltrials.gov/ct2/show/NCT02414178?term=18F-AV-1451&recrs=adf&cond=alzheimers&rank=5

  3. “F 18 T807 Tau PET Imaging of Alzheimer's Disease (T807IND).” ClinicalTrials.gov. Accessed October 9, 2020. https://clinicaltrials.gov/ct2/show/NCT02414347?term=biomarker&recrs=abdf&cond=Alzheimer+Disease&draw=9&rank=79

  4. “F 18 T807 Tau PET Imaging of Progressive Posterior Cortical Dysfunction (IND 123119, Protocol E) (Protocol E).” ClinicalTrials.gov. Accessed October 9, 2019. https://clinicaltrials.gov/ct2/show/NCT02414282?term=biomarker&recrs=abdf&cond=Alzheimer+Disease&draw=10&rank=88

  5. “Longitudinal Early-onset Alzheimer's Disease Study Protocol (LEADS).”ClinicalTrials.gov. Accessed October 9, 2019. https://clinicaltrials.gov/ct2/show/NCT03507257?term=18F-AV-1451&recrs=adf&cond=alzheimers&rank=3

  6. “Tau PET Imaging in Atypical Dementias.” ClinicalTrials.gov. Accessed October 9, 2019. https://clinicaltrials.gov/ct2/show/NCT03283449?term=18F-AV-1451&recrs=adf&cond=alzheimers&rank=10