Biomarkers

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ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
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18F-AV-1451 (F 18 T807)

Method of Measurement (Pre-analytical Tools)
Imaging
Biomarker Measured
Tau
Use
Prognostic
Susceptibility/risk
Stage of Development
Clinical trials
Active vs Completed Trials
Active
Aim/Results

Develop tau imaging technique as an antecedent biomarker of cognitive decline and obtain preliminary data that will support the possibility of detecting cognitive decline in its earliest stages, before the occurrence of dementia. (T807IND)

Target Population/ Population Being Studied

People who are cognitively normal or with mild dementia (T807IND)

Length of Current Trial
5 years (T807IND)
Number of Trial Participants

100 (T807IND)

Estimated Trial Completion
December 2019 (T807IND)
What is Required from Patients

injection of radioactive tracers, mild discomfort, in clinic visit

What is Required from the Health System

PET technician, PET scanner, dyes

Sponsor

Washington University School of Medicine

  1. “Evaluating the Relationship Between Tau PET Imaging and CSF Biomarkers of AD (Alzheimer Disease) in Humans (ADRC proj 1).” ClinicalTrials.gov. Accessed October 9, 2020. https://clinicaltrials.gov/ct2/show/NCT03287765?term=biomarker&recrs=abdf&cond=Alzheimer+Disease&rank=9

  2. “F 18 T807 Tau PET Imaging in Dominantly Inherited Alzheimer's Network (DIAN Project) (AV ADAD).” ClinicalTrials.gov. Accessed October 9, 2019. https://clinicaltrials.gov/ct2/show/NCT02414178?term=18F-AV-1451&recrs=adf&cond=alzheimers&rank=5

  3. “F 18 T807 Tau PET Imaging of Alzheimer's Disease (T807IND).” ClinicalTrials.gov. Accessed October 9, 2020. https://clinicaltrials.gov/ct2/show/NCT02414347?term=biomarker&recrs=abdf&cond=Alzheimer+Disease&draw=9&rank=79

  4. “F 18 T807 Tau PET Imaging of Progressive Posterior Cortical Dysfunction (IND 123119, Protocol E) (Protocol E).” ClinicalTrials.gov. Accessed October 9, 2019. https://clinicaltrials.gov/ct2/show/NCT02414282?term=biomarker&recrs=abdf&cond=Alzheimer+Disease&draw=10&rank=88

  5. “Longitudinal Early-onset Alzheimer's Disease Study Protocol (LEADS).”ClinicalTrials.gov. Accessed October 9, 2019. https://clinicaltrials.gov/ct2/show/NCT03507257?term=18F-AV-1451&recrs=adf&cond=alzheimers&rank=3

  6. “Tau PET Imaging in Atypical Dementias.” ClinicalTrials.gov. Accessed October 9, 2019. https://clinicaltrials.gov/ct2/show/NCT03283449?term=18F-AV-1451&recrs=adf&cond=alzheimers&rank=10