Biomarkers

Share:
ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
Return to the full list of Biomarkers

18kDa translocator protein (TSPO)

Method of Measurement (Pre-analytical Tools)
Imaging
Biomarker Measured
Inflammation
Use
Monitoring
Stage of Development
Preclinical
Active vs Completed Trials
Completed
Aim/Results

Most PET studies have shown that increased TSPO, a key biomarker for measuring brain inflammation, binding is associated with various dementias, suggesting that TSPO has potential as a biomarker to further explore the role of neuroinflammation in dementia pathogenesis and may prove useful in monitoring disease progression.

What is Required from Patients

injection of radioactive tracers, mild discomfort, in clinic visit

What is Required from the Health System

PET technician, PET scanner, dyes

Sponsor

Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA; Office of the Clinical Director, National Institute of Mental Health, Bethesda, MD, USA; Memory Disorders Program, Georgetown University, Washington, DC, USA

  1. Dupont, A. C., Largeau, B., Santiago Ribeiro, M. J., Guilloteau, D., Tronel, C., & Arlicot, N. (2017). Translocator protein-18 kDa (TSPO) positron emission tomography (PET) imaging and its clinical impact in neurodegenerative diseases. International journal of molecular sciences, 18(4), 785. https://www.ncbi.nlm.nih.gov/pubmed/28387722

  2. “FDA Survey to Identify Potential Biomarkers for Qualification.” https://www.fda.gov/downloads/drugs/developmentapprovalprocess/drugdevelopmenttoolsqualificationprogram/ucm459168.pdf

  3. Kreisl, William C., Chul Hyoung Lyoo, Jeih-San Liow, Monica Wei, Joseph Snow, Emily Page, Kimberly J. Jenko et al. "11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease." Neurobiology of Aging, 44 (2016): 53-61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939713/

  4. Kreisl, W. C., Lyoo, C. H., Liow, J. S., Snow, J., Page, E., Jenko, K. J., ... & Innis, R. B. (2017). Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease. Neurobiology of Aging, 51, 132-140. https://www.ncbi.nlm.nih.gov/pubmed/28068564

  5. Kreisl, W. C., Henter, I. D., & Innis, R. B. (2018). Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia. In Advances in Pharmacology (Vol. 82, pp. 163-185). Academic Press. https://www.ncbi.nlm.nih.gov/pubmed/29413519