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4-Hydroxynonenal (HNE)
Method of Measurement (Pre-analytical Tools)
Blood/Plasma
Biomarker Measured
Oxidative stress
Use
Diagnostic
Stage of Development
Clinical trials
Active vs Completed Trials
Completed
Aim/Results
Hydroxynonenal (HNE),a major α,β-unsaturated aldehyde product of n-6 fatty acid oxidation, was higher (P < 0.001) in AD patients compared to controls. HNE was also a good predictor of lipid peroxidation.
What is Required from Patients
blood draw, mild discomfort, in-clinic visits
What is Required from the Health System
phlebotomist, equipped lab (e.g., centrifuge), a way to measure the peptide (e.g., mass spectrometer, protein assay kit, ELISA, or western blot)
Sponsor
Department of Biotechnology, PSG College of Technology, Coimbatore, India.
- Dalleau, S., Baradat, M., Gueraud, F., & Huc, L. (2013). Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance. Cell Death and Differentiation, 20(12), 1615. https://www.ncbi.nlm.nih.gov/pubmed/24096871
- Rani, P., Krishnan, S., & Rani Cathrine, C. (2017). Study on analysis of peripheral biomarkers for alzheimer’s disease diagnosis. Frontiers in Neurology, 8, 328. https://www.ncbi.nlm.nih.gov/pubmed/28769864
- Skoumalová, A., & Hort, J. (2012). Blood markers of oxidative stress in Alzheimer's disease. Journal of Cellular and Molecular Medicine, 16(10), 2291-2300. https://www.ncbi.nlm.nih.gov/pubmed/22564475