Biomarkers

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ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
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ADDIA blood biomarkers

Method of Measurement (Pre-analytical Tools)
Blood/Plasma
Biomarker Measured
Other
Use
Diagnostic
Stage of Development
Clinical trials
Active vs Completed Trials
Active
Aim/Results

Validate the performance of ADDIA' blood biomarkers for diagnosis of Alzheimer's disease. ADDIA clinical study is a multi-centre, non-interventional, prospective, proof-of-performance study with only one visit.

Target Population/ Population Being Studied

400 patients with Alzheimer's disease (AD) (200 patients with mild AD, 200 patients with moderate-to-severe AD), 200 patients with non-Alzheimer's neurodegenerative diseases (NAD), and 200 controls (healthy as compared to their age)

Length of Current Trial
18 months
Number of Trial Participants

800

Estimated Trial Completion
September 2018
What is Required from Patients

blood draw, mild discomfort, in clinic visits

What is Required from the Health System

phlebotomist, equipped lab (e.g., centrifuge), a way to measure the peptide (e.g., mass spectrometer, protein assay kit, ELISA, western blot, or qPCR)

Sponsor

Amoneta Diagnostics SAS; European Commission; Firalis SA; University Hospital, Strasbourg; Centre Hospitalier Universitaire Vaudois; IRCCS Centro San Giovanni di Dio Fatebenefratelli; Hôpitaux Civils de Colmar; Istanbul University; Assistance Publique - Hôpitaux de Paris ;University Hospital, Lille; University Hospital, Geneva; Cliniques universitaires Saint-Luc- Université Catholique de Louvain; Erasme University Hospital; University Hospital, Montpellier; Centre Hospitalier Universitaire de Besancon; Centre Hospitalier Universitaire de Nice

  1. “ADDIA Proof-of-Performance Clinical Study (ADDIA).” ClinicalTrials.gov. Accessed July 28, 2018. https://clinicaltrials.gov/ct2/show/NCT03030586?term=biomarker&recrs=abdf&cond=Alzheimer+Disease&draw=3&rank=30

  2. “Diagnosis of Alzheimer's Disease in a single drop of blood: "ADDIA ".” https://www.addia-project-h2020.eu/