Biomarkers

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ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
Return to the full list of Biomarkers

APOE4

Method of Measurement (Pre-analytical Tools)
Blood/Plasma
Other bodily fluids
Biomarker Measured
Genetic variation/DNA
Use
Susceptibility/risk
Stage of Development
In use (FDA approved)
Active vs Completed Trials
Completed
Aim/Results

There are three types of the APOE gene, called alleles: APOE2, E3 and E4. Everyone has two copies of the gene and the combination determines your APOE "genotype"—E2/E2, E2/E3, E2/E4, E3/E3, E3/E4, or E4/E4. The APOE4 allele, present in approximately 10-15% of people, increases the risk for Alzheimer's and lowers the age of onset.

What is Required from Patients

blood draw, mild discomfort, in clinic visits OR noninvasive, at home kits that can take another form of bodily fluid (e.g., saliva)

What is Required from the Health System

phlebotomist (if the patient is using a blood sample), equipped lab (e.g., centrifuge), a way to measure the peptide (e.g., mass spectrometer, protein assay kit, ELISA, or western blot)

Sponsor

Mulitple providers

  1. “ALZHEIMER’S BIOMARKERS, EXPLAINED.” https://www.alzdiscovery.org/news-room/blog/alzheimers-biomarkers-explained

  2. “APOE gene.” https://ghr.nlm.nih.gov/gene/APOE

  3. “WHAT APOE MEANS FOR YOUR HEALTH.” https://www.alzdiscovery.org/cognitive-vitality/blog/what-apoe-means-for-your-health