Biomarkers

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ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
Return to the full list of Biomarkers

Circulatory MicroRNAs (miRNAs)

Method of Measurement (Pre-analytical Tools)
Blood/Plasma
Biomarker Measured
Cell signaling
Use
Unknown
Stage of Development
Preclinical
Active vs Completed Trials
Completed
Aim/Results

Intracellular miRNAs modulate mRNA activity through target-specific binding and play a crucial role in intercellular communications, but deregulated miRNAs come out from cells and frequently circulate in extracellular body fluids as part of various human diseases. While there does seem to be an association between circulating miRNA level, which specific miRNA changes relate to AD still needs to be specified more clearly.

What is Required from Patients

blood draw, mild discomfort, in clinic visits

What is Required from the Health System

phlebotomist, equipped lab (e.g., centrifuge), a way to measure mRNA (e.g., qPCR)

  1. Kumar, S., & Reddy, P. H. (2016). Are circulating microRNAs peripheral biomarkers for Alzheimer's disease?. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1862(9), 1617-1627. https://www.ncbi.nlm.nih.gov/pubmed/27264337

  2. Kumar, S., Vijayan, M., Bhatti, J. S., & Reddy, P. H. (2017). MicroRNAs as peripheral biomarkers in aging and age-related diseases. In Progress in molecular biology and translational science (Vol. 146, pp. 47-94). Academic Press. https://www.ncbi.nlm.nih.gov/pubmed/28253991

  3. Mushtaq, G., H Greig, N., Anwar, F., A Zamzami, M., Choudhry, H., M Shaik, M., ... & A Kamal, M. (2016). miRNAs as circulating biomarkers for Alzheimer’s disease and Parkinson’s disease. Medicinal Chemistry, 12(3), 217-225. https://www.ncbi.nlm.nih.gov/pubmed/26527155

  4. Sharma, N., & Singh, A. N. (2016). Exploring biomarkers for Alzheimer’s disease. Journal of clinical and diagnostic research: JCDR, 10(7), KE01. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020308/