Biomarkers

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ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
Return to the full list of Biomarkers

hFABP

Method of Measurement (Pre-analytical Tools)
CSF
Biomarker Measured
Neuronal damage
Use
Diagnostic
Stage of Development
Clinical trials
Active vs Completed Trials
Completed
Aim/Results

Levels of heart fatty acid binding protein in cerebrospinal fluid are significantly higher in people with Alzheimer’s disease compared with controls (effect size = 1.394, p <0.0001). This effect was consistent across the handful of available studies and highly significant. hFABP is expressed in the brain. Only the case for CSF levels not plasma/serum levels.

What is Required from Patients

Invasive lumbar puncture, discomfort, recovery time in clinic to decrease risk of spinal fluid leakage

What is Required from the Health System

physician who can preform a lumbar puncture as well as a clinic designed for this testing, equipped lab (e.g., centrifuge), a way to measure the peptide (e.g., mass spectrometer, protein assay kit, ELISA, or western blot)

Sponsor

Data collected by multiple groups. Alzforum meta analysis.

  1. “Alzheimer's Disease vs Control: hFABP (CSF).” Alzbiomarker. https://www.alzforum.org/alzbiomarker/meta-analysis/alzheimers-disease-vs-control-hfabp-csf

  2. Desikan, R. S., Thompson, W. K., Holland, D., Hess, C. P., Brewer, J. B., Zetterberg, H., ... & Dale, A. M. (2013). Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration. Molecular Neurodegeneration, 8(1), 39. https://www.ncbi.nlm.nih.gov/pubmed/24088526

  3. Guo, L. H., Alexopoulos, P., & Perneczky, R. (2013). Heart-type fatty acid binding protein and vascular endothelial growth factor: cerebrospinal fluid biomarker candidates for Alzheimer’s disease. European archives of psychiatry and clinical neuroscience, 263(7), 553-560. https://www.ncbi.nlm.nih.gov/pubmed/23591828

  4. Olsson, B., Hertze, J., Ohlsson, M., Nägga, K., Höglund, K., Basun, H., ... & Zetterberg, H. (2013). Cerebrospinal fluid levels of heart fatty acid binding protein are elevated prodromally in Alzheimer's disease and vascular dementia. Journal of Alzheimer's Disease, 34(3), 673-679. https://www.ncbi.nlm.nih.gov/pubmed/23254629