Interleukin 10 (IL-10)
IL-10 cytokine which can act as a marker from inflammation. High levels of IL-10 were significantly associated with amyloid deposition in healthy controls, suggesting that these two biomarkers might be used to detect at risk individuals.
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blood draw, mild discomfort, in clinic visits
phlebotomist, equipped lab (e.g., centrifuge), a way to measure the peptide (e.g., mass spectrometer, protein assay kit, ELISA, western blot, or qPCR)
School of Medical Sciences, Edith Cowan University, Joondalup, WA 6027, Australia;Co-operative Research Centre for Mental Health, Carlton, VIC 3053, Australia;CSIRO Digital Productivity Flagship, Brisbane, QLD 4029, Australia;University of North Texas Health Science Center, Fort Worth, 76107, Texas, USA; Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, WA 6150, Australia; The Florey Institute, The University of Melbourne, Parkville, VIC 3052, Australia; Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC 3084, Australia; National Ageing Research Institute, Parkville, VIC 3052, Australia; Academic Unit for Psychiatry of Old age, St. George’s Hospital, The University of Melbourne, Parkville, VIC 3052, Australia; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA 6009, Australia; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia; Department of Psychology, Macquarie University, Sydney, NSW 2109, Australia; CSIRO; The University of Melbourne, Parkville, VIC 3052, Australia; Cogstate Ltd., Melbourne, VIC 3000, Australia; Alzheimer Australia Vic, Hawthorne, VIC 3122, Australia; St. Vincent Hospital, Fitzroy, VIC 3065, Australia; University of Western Australia, Crawley, WA 6009, Australia; School of Biomedical Sciences, Curtin University, Bentley, WA 6102, Australia
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“IL10 interleukin 10 [ Homo sapiens (human) ].” Gene ID;NCBI. https://www.ncbi.nlm.nih.gov/gene/3586
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Pedrini, S., Gupta, V. B., Hone, E., Doecke, J., O’bryant, S., James, I., ... & Masters, C. L. (2017). A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort. Scientific Reports, 7(1), 14057. https://www.ncbi.nlm.nih.gov/pubmed/29070909
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Sharma, N., & Singh, A. N. (2016). Exploring biomarkers for Alzheimer’s disease. Journal of clinical and diagnostic research: JCDR, 10(7), KE01. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020308/
- Wang, T., Xiao, S., Liu, Y., Lin, Z., Su, N., Li, X., ... & Fang, Y. (2014). The efficacy of plasma biomarkers in early diagnosis of Alzheimer's disease. International journal of geriatric psychiatry, 29(7), 713-719. https://www.ncbi.nlm.nih.gov/pubmed/24318929