Biomarkers

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ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
Return to the full list of Biomarkers

Interleukin 1β (IL- 1β) (plasma)

Method of Measurement (Pre-analytical Tools)
Blood/Plasma
Biomarker Measured
Inflammation
Use
Diagnostic
Stage of Development
Clinical trials
Active vs Completed Trials
Completed
Aim/Results

Serum levels of inflammatory cytokine IL-1β are significantly increased in AD patients. This pattern was also observed in adult individuals with an abnormal MMSE test, indicating it may serve as an early biomarker of MCI and AD development.

What is Required from Patients

blood draw, mild discomfort, in clinic visits

What is Required from the Health System

phlebotomist, equipped lab (e.g., centrifuge), a way to measure the peptide (e.g., mass spectrometer, protein assay kit, ELISA, western blot, or qPCR)

  1. Castillo, L. M., Moreno, E., Rodríguez-Agudelo, Y., Chávez-Oliveros, M., Trujillo, Z., Espinosa, B., ... & Guevara, J. (2015). IL-1β, TNF-α and Sambucus nigra Reactive Serum Proteins as Biomarkers of Mild Cognitive Impairment and Alzheimer Disease Progression. Advances in Alzheimer's Disease, 4(04), 99. https://www.scirp.org/journal/PaperInformation.aspx?PaperID=61894

  2. Dursun, E., Gezen-Ak, D., Hanağası, H., Bilgiç, B., Lohmann, E., Ertan, S., ... & Gündüz, A. (2015). The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease. Journal of Neuroimmunology, 283, 50-57. https://www.ncbi.nlm.nih.gov/pubmed/26004156

  3. Sharma, N., & Singh, A. N. (2016). Exploring biomarkers for Alzheimer’s disease. Journal of clinical and diagnostic research: JCDR, 10(7), KE01. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020308/