Biomarkers

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ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
Return to the full list of Biomarkers

Matrix metalloproteinase 3 (MMP3)

Method of Measurement (Pre-analytical Tools)
Blood/Plasma
CSF
Biomarker Measured
Amyloid
Tau
Use
Diagnostic
Monitoring
Active vs Completed Trials
Active
Aim/Results

Plasma and CSF levels of MMP3 were significantly lower in AD patients than in controls. Moreover, plsama levels of MMP3 activity was significantly correlated with the MMSE scores

What is Required from Patients

Invasive lumbar puncture, discomfort, recovery time in clinic to decrease risk of spinal fluid leakage OR blood draw, mild discomfort, in clinic visits

What is Required from the Health System

Physician who can preform a lumbar puncture as well as a clinic designed for this testing, equipped lab (e.g., centrifuge), a way to measure the peptide (e.g., mass spectrometer, protein assay kit, ELISA, or western blot) OR phlebotomist, equipped lab (e.g., centrifuge), a way to measure the peptide (e.g., mass spectrometer, protein assay kit, ELISA, western blot, or qPCR)

Sponsor

Xuan Wu Hospital of the Capital Medical University, Beijing,; Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing; Qingdao University; Qingdao Huangdao District People’s Hospital, Qingdao; Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China; Massachusetts General Hospital, Harvard Medical School; Perelman School of Medicine of the University of Pennsylvania

  1. Guerreiro, R., Bras, J., Toombs, J., Heslegrave, A., Hardy, J., & Zetterberg, H. (2015). Genetic variants and related biomarkers in sporadic Alzheimer’s disease. Current genetic medicine reports, 3(1), 19-25. https://www.ncbi.nlm.nih.gov/pubmed/25664224

  2. Trombetta, B. A., Carlyle, B. C., Koenig, A. M., Shaw, L. M., Trojanowski, J. Q., Wolk, D. A., ... & Arnold, S. E. (2018). The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer’s disease. PloS one, 13(3), e0193707. https://www.ncbi.nlm.nih.gov/pubmed/29505610

  3. Wang, X. X., Tan, M. S., Yu, J. T., & Tan, L. (2014). Matrix metalloproteinases and their multiple roles in Alzheimer’s disease. BioMed research international, 2014. https://www.ncbi.nlm.nih.gov/pubmed/25050378