Biomarkers

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ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
Return to the full list of Biomarkers

Retinal thinning

Method of Measurement (Pre-analytical Tools)
Optical
Biomarker Measured
Vasculature
Use
Susceptibility/risk
Stage of Development
Clinical trials
Active vs Completed Trials
Completed
Aim/Results

Previous studies have reported changes to the retinal architecture in people already diagnosed with AD or with mild cognitive impairment. Preliminary new research indicates retinal thinning may be observed even in the preclinical stage of Alzheimer’s disease.

What is Required from Patients

noninvasive images of the eye, in clinic visit

What is Required from the Health System

eye imager

Sponsor

Washington University, St. Louis; University of Technology Sydney; Macquarie University; KaRa Institute of Neurological Diseases, Macquarie Park; Australian e-Health Research Centre, CSIRO Health and Biosecurity; Singapore Eye Research Institute; Department of Geriatric Medicine, Khoo Teck Puat Hospital; Memory Aging and Cognition Centre, National University Health System, Singapore

  1. Cheung, C. Y. L., Ong, Y. T., Ikram, M. K., Ong, S. Y., Li, X., Hilal, S., ... & Chen, C. P. (2014). Microvascular network alterations in the retina of patients with Alzheimer's disease. Alzheimer's & Dementia, 10(2), 135-142.

  2. “Does Retinal Thinning Reflect Early Alzheimer’s?” Alzforum. https://www.alzforum.org/news/research-news/does-retinal-thinning-reflect-early-alzheimers

  3. Golzan, S. M., Goozee, K., Georgevsky, D., Avolio, A., Chatterjee, P., Shen, K., ... & Martins, R. N. (2017). Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease. Alzheimer's Research & Therapy, 9(1), 13. https://www.ncbi.nlm.nih.gov/pubmed/28253913

  4. O’bryhim, B. E., Apte, R. S., Kung, N., Coble, D., & Van Stavern, G. P. (2018). Association of preclinical Alzheimer disease with optical coherence tomographic angiography findings. Jama Ophthalmology, 136(11), 1242-1248. https://www.ncbi.nlm.nih.gov/pubmed/30352114