Tau in the biological fluids (ECTAUSOME)
Decipher the nature of Tau secreted in plasma and cerebrospinal fluids collected from healthy controls to AD patients, and to decipher if the presence of tau inside vesicles is influenced by the pathology.
People with asymptomatic cases with high risk to develop AD, isolated cognitive complaint, Prodromal AD, mild to moderate probable AD-type dementia, and healthy controls
100
blood draw, mild discomfort, in clinic visits OR noninvasive, at home kits that can take another form of bodily fluid (e.g., saliva)
phlebotomist (if the patient is using a blood sample), equipped lab (e.g., centrifuge), a way to measure the peptide (e.g.,mass spectrometer, protein assay kit, ELISA, or western blot)
University Hospital, Lille
“Ectosomes, New Biomarkers of Tau Pathology? (ECTAUSOME).” ClinicalTrials.gov. Accessed October 11, 2019. https://clinicaltrials.gov/ct2/show/NCT03381482?term=biomarker&recrs=abdf&cond=Alzheimer+Disease&draw=2&rank=15