Biomarkers

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ResearchersAgainstAlzheimer's would like to thank Roche Diagnostics for their support of this project.
Return to the full list of Biomarkers

Vascular Cell Adhesion Molecule 1 (VCAM-1)

Method of Measurement (Pre-analytical Tools)
Blood/Plasma
Biomarker Measured
Neuronal damage
Use
Diagnostic
Monitoring
Prognostic
Stage of Development
Clinical trials
Active vs Completed Trials
Completed
Aim/Results

VCAM-1 is a membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction.Compared with the controls, plasma levels of VCAM-1 (p< 0.001) were significantly higher in the patients and significantly reflected the severity of dementia (p< 0.001). In addition, VCAM-1 levels showed an association with macro- and micro- white matter changes especially in the superior longitudinal fasciculus (p< 0.001), posterior thalamic radiation (p=0.002), stria terminals (p=0.002) and corpus callosum (p=0.009), and were independent of, age and cortical volume. These tracts show significant association with MMSE, short term memory and visuospatial function. Simiarly, VCAM-1 level correlated significantly with short-term memory (p=0.026) and drawing (p=0.025) scores in the AD patients.

What is Required from Patients

blood draw, mild discomfort, in clinic visits

What is Required from the Health System

phlebotomist, equipped lab (e.g., centrifuge), a way to measure the peptide (e.g.,mass spectrometer, protein assay kit, ELISA, western blot, or qPCR)

Sponsor

Department of Biological Science, National Sun Yat-sen University, Kaohsiung, Taiwan; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Taiwan; CSIRO Preventative Health Flagship: Mathematics, Informatics and Statistics, Perth; The University of Melbourne; Edith Cowan University; National ICT of Australia (NICTA); Alzheimer’s Disease Neuroimaging Initiative; Australian Imaging, Biomarkers and Lifestyle Study Research Group

  1. Burnham, S. C., Faux, N. G., Wilson, W., Laws, S. M., Ames, D., Bedo, J., ... & Jones, G. (2014). A blood-based predictor for neocortical Aβ burden in Alzheimer’s disease: results from the AIBL study. Molecular Psychiatry, 19(4), 519. https://www.ncbi.nlm.nih.gov/pubmed/23628985

  2. Burnham, S. C., Rowe, C. C., Baker, D., Bush, A. I., Doecke, J. D., Faux, N. G., ... & Rainey-Smith, S. (2016). Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up. Neurology, 87(11), 1093-1101. https://www.ncbi.nlm.nih.gov/pubmed/27534714

  3. Huang, C. W., Tsai, M. H., Chen, N. C., Chen, W. H., Lu, Y. T., Lui, C. C., ... & Chang, C. C. (2015). Clinical significance of circulating vascular cell adhesion molecule-1 to white matter disintegrity in Alzheimer’s dementia. Thrombosis and Haemostasis, 114(06), 1230-1240. https://www.ncbi.nlm.nih.gov/pubmed/26289958

  4. “VCAM1 vascular cell adhesion molecule 1 [ Homo sapiens (human) ].” NCBI:Gene. https://www.ncbi.nlm.nih.gov/gene/7412