Biomarkers

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Summary of Biomarker Analysis

  • Method of Measurement

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  • Biomarker Measured

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  • Biomarker Categories

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Summary completed October 2019

Biomarkers for Alzheimer’s Disease

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  • Biomarker
Biomarker
Aβ1-17 (Aβ17)
Biomarker Measured
Blood/Plasma
Method of Measurement
Amyloid
Use
Diagnostic
Stage of Development
Preclinical
Biomarker
Plasma lipoproteome
Biomarker Measured
Blood/Plasma
Method of Measurement
Neuronal damage
Use
Diagnostic
Stage of Development
Clinical trials
Biomarker
α-synuclein
Biomarker Measured
CSF
Method of Measurement
Amyloid
Use
Diagnostic
Stage of Development
Clinical trials
Biomarker
Pramlintide challenge blood test (DTAD)
Biomarker Measured
Blood/Plasma
Method of Measurement
Amyloid
Use
Diagnostic, Predictive
Stage of Development
Clinical trials
Biomarker
Retinal Imaging (RetAD)
Biomarker Measured
Optical
Method of Measurement
Vasculature
Use
Diagnostic, Monitoring
Stage of Development
Clinical trials
Biomarker
4-Hydroxynonenal (HNE)
Biomarker Measured
Blood/Plasma
Method of Measurement
Oxidative stress
Use
Diagnostic
Stage of Development
Clinical trials
Biomarker
4-Hydroxynonenal (HNE)
Biomarker Measured
Blood/Plasma
Method of Measurement
Oxidative stress
Use
Diagnostic
Stage of Development
Clinical trials
Biomarker
4-Hydroxynonenal (HNE)
Biomarker Measured
Blood/Plasma
Method of Measurement
Oxidative stress
Use
Diagnostic
Stage of Development
Clinical trials
Biomarker
18F-AV-1451 (F 18 T807)
Biomarker Measured
Imaging
Method of Measurement
Tau
Use
Prognostic, Susceptibility/risk
Stage of Development
Clinical trials
Biomarker
Proteostasis-related biomarkers
Biomarker Measured
CSF
Method of Measurement
Amyloid, Inflammation, Neuronal damage, Tau, Other
Use
Diagnostic, Monitoring, Susceptibility/risk
Stage of Development
Clinical trials
Biomarker
Single Photon Emission Computed Tomography (SPECT) with DaTscan (SPECT-DaTscan) and CSF biomarkers (CLEM)
Biomarker Measured
Imaging, CSF
Method of Measurement
Unknown
Use
Prognostic, Predictive
Stage of Development
Clinical trials
Biomarker
18F-AV-1451 (F 18 T807)
Biomarker Measured
Imaging
Method of Measurement
Tau
Use
Prognostic, Susceptibility/risk
Stage of Development
Clinical trials
Biomarker
Sphingolipids
Biomarker Measured
Blood/Plasma
Method of Measurement
Unknown
Use
Susceptibility/risk
Stage of Development
Clinical trials
Biomarker
18F-AV-1451 (F 18 T807)
Biomarker Measured
Imaging
Method of Measurement
Tau
Use
Prognostic, Susceptibility/risk
Stage of Development
Clinical trials
Biomarker
Retinal thinning
Biomarker Measured
Optical
Method of Measurement
Vasculature
Use
Susceptibility/risk
Stage of Development
Clinical trials
Biomarker
18F-AV-1451 (F 18 T807)
Biomarker Measured
Imaging
Method of Measurement
Tau
Use
Prognostic, Susceptibility/risk
Stage of Development
Clinical trials
Biomarker
sTREM2
Biomarker Measured
CSF
Method of Measurement
Neuronal damage
Use
Diagnostic, Monitoring
Stage of Development
Clinical trials
Biomarker
18F-AV-1451 (F 18 T807)
Biomarker Measured
Imaging
Method of Measurement
Tau
Use
Prognostic, Susceptibility/risk
Stage of Development
Clinical trials
Biomarker
Synaptic Injury and Functional Connectivity
Biomarker Measured
Imaging, CSF
Method of Measurement
Neuronal damage
Use
Diagnostic
Stage of Development
Clinical trials
Biomarker
[18F]MK-6240 ([18F]MNI-946)
Biomarker Measured
Imaging
Method of Measurement
Tau
Use
Monitoring, Pharmacodynamic/response, Susceptibility/risk
Stage of Development
Clinical trials
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